Dismorfik sendromundaki transkripsiyonel profilin hesapsal analizi

Translated title of the contribution: Computational analysis of transcriptional profiling in dysmorphic syndrome

Hasan H. Otu, Handan Can, Namik Kaya, Laila Al-alwan, Pinar Ozand, Mehmet S. Inan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we present comparative expression, functional and pathway analysis of transcriptional profiling of a dysmorphic patient and its matched control using whole blood and fibroblast cells in an attempt to identify genetic changes in Dysmorphic disorders and developmental genes at large. Normalization was done by first finding an invariant set whose expression levels do not change significantly among the chips and then using this set to normalize raw probe values with a smoothing spline invariant set normalization method. Genes with significant change in expression were identified using the lower confidence bound of fold change and these genes were used to perform functional analyses within the context of Gene Ontology categories and biological pathwyas. Our results indicate that genes with altered expression levels are cell-type specific, activated biological categories are mostly developmental related such as skeletal and muscular system and genes dysregulated in both cell types effect cAMP dependent PKA pathway and consequently the CREB cycle.

Translated title of the contributionComputational analysis of transcriptional profiling in dysmorphic syndrome
Original languageTurkish
Title of host publication2007 IEEE 15th Signal Processing and Communications Applications, SIU
DOIs
StatePublished - 2007
Event2007 IEEE 15th Signal Processing and Communications Applications, SIU - Eskisehir, Turkey
Duration: Jun 11 2007Jun 13 2007

Publication series

Name2007 IEEE 15th Signal Processing and Communications Applications, SIU

Conference

Conference2007 IEEE 15th Signal Processing and Communications Applications, SIU
CountryTurkey
CityEskisehir
Period6/11/076/13/07

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Communication
  • Signal Processing

Fingerprint Dive into the research topics of 'Computational analysis of transcriptional profiling in dysmorphic syndrome'. Together they form a unique fingerprint.

  • Cite this

    Otu, H. H., Can, H., Kaya, N., Al-alwan, L., Ozand, P., & Inan, M. S. (2007). Dismorfik sendromundaki transkripsiyonel profilin hesapsal analizi. In 2007 IEEE 15th Signal Processing and Communications Applications, SIU [4298831] (2007 IEEE 15th Signal Processing and Communications Applications, SIU). https://doi.org/10.1109/SIU.2007.4298831