Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop

Theodore Sakellaropoulos, Junguk Hur, Ioannis N. Melas, Ellen Y. Guo, Leonidas Alexopoulos, Mohammad Bohlooly, Jane P.F. Bai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Some successes have been achieved in the war on cancer over the past 30 years with recent efforts on protein kinase inhibitors. Nonetheless, we are still facing challenges due to cancer evolution. Cancers are complex and heterogeneous due to primary and secondary mutations, with phenotypic and molecular heterogeneity manifested among patients of a cancer, and within an individual patient throughout the disease course. Our understanding of cancer genomes has been facilitated by advances in omics and in bioinformatics technologies; major areas in cancer research are advancing in parallel on many fronts. Computational methods have been developed to decipher the molecular complexity of cancer and to identify driver mutations in cancers. Utilizing the identified driver mutations to develop effective therapy would require biological linkages from cellular context to clinical implication; for this purpose, computational mining of biomedical literature facilitates utilization of a huge volume of biomedical research data and knowledge. In addition, frontier technologies, such as genome editing technologies, are facilitating investigation of cancer mutations, and opening the door for developing novel treatments to treat diseases. We will review and highlight the challenges of treating cancers, which behave like moving targets due to mutation and evolution, and the current state-of-the-art research in the areas mentioned above.

Original languageEnglish (US)
Title of host publicationAdvances in Protein Chemistry and Structural Biology
EditorsRossen Donev
PublisherAcademic Press Inc.
Pages147-179
Number of pages33
ISBN (Print)9780128047958
DOIs
StatePublished - 2016

Publication series

NameAdvances in Protein Chemistry and Structural Biology
Volume102
ISSN (Print)1876-1623

Keywords

  • Computation
  • Driver mutations
  • Genome editing
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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    Sakellaropoulos, T., Hur, J., Melas, I. N., Guo, E. Y., Alexopoulos, L., Bohlooly, M., & Bai, J. P. F. (2016). Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop. In R. Donev (Ed.), Advances in Protein Chemistry and Structural Biology (pp. 147-179). (Advances in Protein Chemistry and Structural Biology; Vol. 102). Academic Press Inc.. https://doi.org/10.1016/bs.apcsb.2015.09.005