Computational modelling and simulation of disposition and fate of medication

Dietmar P.F. Möller; Hamid Vakilzadian; Jochen Wittmann

Computational modelling and simulation of disposition and fate of medication

Dietmar P.F. Möller, Hamid Vakilzadian, Jochen Wittmann

Electrical & Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this case study, the ingestion and subsequent metabolism of a medication in an individual are examined through computational modeling and simulation. A multi-compartment model is used to study ingestion, distribution, and metabolism of a medication in an individual. This paper provides background information on the mechanism of action of medication in pharmacological terms and the significance of pharmacokinetic parameters in determining the efficacy of a medication, in particular, the medication that is ingested orally. The orally taken medication enters the gastrointestinal tract from where it is then distributed throughout the bloodstream of the individual to be metabolized and eliminated.

Original language	English (US)
Title of host publication	Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011
Pages	76-82
Number of pages	7
State	Published - 2011
Event	4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011 - The Hague, Netherlands Duration: Jun 27 2011 → Jun 30 2011

Publication series

Name	Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011

Conference

Conference	4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011
Country/Territory	Netherlands
City	The Hague
Period	6/27/11 → 6/30/11

Keywords

Drug ingestion
Drug metabolism
Medicine
Modeling and simulation (M&S)
Pharmacokinetic

ASJC Scopus subject areas

Modeling and Simulation

Cite this

Computational modelling and simulation of disposition and fate of medication. / Möller, Dietmar P.F.; Vakilzadian, Hamid; Wittmann, Jochen.
Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. 2011. p. 76-82 (Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Möller, DPF, Vakilzadian, H & Wittmann, J 2011, Computational modelling and simulation of disposition and fate of medication. in Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011, pp. 76-82, 4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011, The Hague, Netherlands, 6/27/11.

@inproceedings{7593a3a98adf47d0920336bb33a7c16e,

title = "Computational modelling and simulation of disposition and fate of medication",

abstract = "In this case study, the ingestion and subsequent metabolism of a medication in an individual are examined through computational modeling and simulation. A multi-compartment model is used to study ingestion, distribution, and metabolism of a medication in an individual. This paper provides background information on the mechanism of action of medication in pharmacological terms and the significance of pharmacokinetic parameters in determining the efficacy of a medication, in particular, the medication that is ingested orally. The orally taken medication enters the gastrointestinal tract from where it is then distributed throughout the bloodstream of the individual to be metabolized and eliminated.",

keywords = "Drug ingestion, Drug metabolism, Medicine, Modeling and simulation (M&S), Pharmacokinetic",

author = "M{\"o}ller, {Dietmar P.F.} and Hamid Vakilzadian and Jochen Wittmann",

year = "2011",

language = "English (US)",

isbn = "9781617829512",

series = "Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011",

pages = "76--82",

booktitle = "Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011",

note = "4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011 ; Conference date: 27-06-2011 Through 30-06-2011",

}

TY - GEN

T1 - Computational modelling and simulation of disposition and fate of medication

AU - Möller, Dietmar P.F.

AU - Vakilzadian, Hamid

AU - Wittmann, Jochen

PY - 2011

Y1 - 2011

N2 - In this case study, the ingestion and subsequent metabolism of a medication in an individual are examined through computational modeling and simulation. A multi-compartment model is used to study ingestion, distribution, and metabolism of a medication in an individual. This paper provides background information on the mechanism of action of medication in pharmacological terms and the significance of pharmacokinetic parameters in determining the efficacy of a medication, in particular, the medication that is ingested orally. The orally taken medication enters the gastrointestinal tract from where it is then distributed throughout the bloodstream of the individual to be metabolized and eliminated.

AB - In this case study, the ingestion and subsequent metabolism of a medication in an individual are examined through computational modeling and simulation. A multi-compartment model is used to study ingestion, distribution, and metabolism of a medication in an individual. This paper provides background information on the mechanism of action of medication in pharmacological terms and the significance of pharmacokinetic parameters in determining the efficacy of a medication, in particular, the medication that is ingested orally. The orally taken medication enters the gastrointestinal tract from where it is then distributed throughout the bloodstream of the individual to be metabolized and eliminated.

KW - Drug ingestion

KW - Drug metabolism

KW - Medicine

KW - Modeling and simulation (M&S)

KW - Pharmacokinetic

UR - http://www.scopus.com/inward/record.url?scp=84871313305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871313305&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84871313305

SN - 9781617829512

T3 - Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011

SP - 76

EP - 82

BT - Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011

T2 - 4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011

Y2 - 27 June 2011 through 30 June 2011

ER -

Computational modelling and simulation of disposition and fate of medication

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this