Computational optimization of a novel atraumatic catheter for local drug delivery in coronary atherosclerotic plaques

Research output: Contribution to journalArticle

Abstract

Early identification and treatment of high-risk plaques before they rupture, and precipitate adverse events constitute a major challenge in cardiology today. Computational simulations are a time- and cost-effective way to study the performance, and to optimize a system. The main objective of this work is to optimize the flow of a novel atraumatic local drug delivery catheter for the treatment of coronary atherosclerosis. The mixing and spreading effectiveness of a drug fluid was analyzed utilizing computational fluid dynamics (CFD) in a coronary artery model. The optimum infusion flow of the nanoparticle-carrying drug fluid was found by maximizing the drug volume fraction and minimizing drug velocity at the artery wall, while maintaining acceptable wall shear stress (WSS). Drug velocities between 15 m/s and 20 m/s are optimum for local drug delivery. The resulting parameters from this study will be used to fabricate customized prototypes for future in-vivo experiments.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalMedical Engineering and Physics
Volume79
DOIs
StatePublished - May 2020

Keywords

  • Computational fluid dynamics (CFD)
  • Coronary atherosclerosis
  • Drug delivery catheter
  • Local drug delivery
  • Non-Newtonian blood flow

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Computational optimization of a novel atraumatic catheter for local drug delivery in coronary atherosclerotic plaques'. Together they form a unique fingerprint.

  • Cite this