Computational simulation of the deformation of neuronal cells

Guoxin Cao, You Zhou, Jeong Soon Lee, Jung Yul Lim, Shailesh Ganpule, Namas Chandra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A numerical simulation (finite element method (FEM)) is used to determine the local mechanical response of a neuron based on the real neuron geometry. The real 3D geometry of a neuron can be constructed from the 2D confocal image stack which is taken per micron along the thickness direction from the top surface of neuron to the substrate. By matching the simulated deformation of the neuron with the measured results from the confocal microscopy images, the relative strength of the neuron components can be determined based on the reverse analysis of FEM. Then, the neuron local mechanical response and the relationship between the local response and the global applied deformation can be obtained, which will be the first step of building the mechanical injury model of neuron.

Original languageEnglish (US)
Title of host publicationASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010
Pages179-180
Number of pages2
DOIs
StatePublished - 2010
EventASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010 - Vancouver, BC, Canada
Duration: Nov 12 2010Nov 18 2010

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume2

Conference

ConferenceASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010
CountryCanada
CityVancouver, BC
Period11/12/1011/18/10

ASJC Scopus subject areas

  • Mechanical Engineering

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    Cao, G., Zhou, Y., Lee, J. S., Lim, J. Y., Ganpule, S., & Chandra, N. (2010). Computational simulation of the deformation of neuronal cells. In ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010 (pp. 179-180). (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 2). https://doi.org/10.1115/IMECE2010-37949