Computerized cognitive training (Cct) versus yoga impact on 12 month post intervention cognitive outcome in individuals with mild cognitive impairment

Vaishali S. Phatak, Glenn E. Smith, Dona Locke, Anne Shandera-Ochsner, Pamela M. Dean, Colleen Ball, Gianna Gutierrez, Melanie J. Chandler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


There is currently limited and mixed evidence for the cognitive benefits of Computerized Cognitive Training (CCT) and yoga in persons with Mild Cognitive Impairment (pwMCI). The objective of this study was to investigate the benefit of computerized cognitive training (CCT) vs. physical (yoga) intervention on cognitive abilities. Participants in this study were part of the larger Mayo Clinic’s Healthy Action to Benefit Independence and Thinking (HABIT) program comparative effectiveness trial. The HABIT program is designed for pwMCI and their care partner and consists of five behavioral interventions: CCT, Memory Support System-Calendar (MSS-Calendar), wellness education, support groups, and yoga. The subtractive study design randomly withheld one of the interventions for a total of five study arms. Longitudinal mixed-effects regression models were used to investigate the hypothesis that CCT and yoga has a greater positive impact on psychomo-tor and basic attention abilities at 12 months post-intervention as compared to the other HABIT interventions. Findings showed CCT had a positive impact compared to yoga on the Cogstate psy-chomotor/attention composite at 12 months post-intervention (ES = 0.54; unadjusted p value = 0.007, adjusted p value = 0.021). The impact of yoga or combining CCT with yoga did not show statistically significant improvement. Continued CCT practice at home showed further benefit on psychomo-tor/attention at 12 months post-intervention. There was no significant benefit of CCT or yoga on Cogstate learning/working memory composite.

Original languageEnglish (US)
Article number988
JournalBrain Sciences
Issue number8
StatePublished - Aug 2021


  • Behavioral interventions
  • Clinical trial
  • Cognitive enrichment
  • Computerized cognitive training (CCT)
  • Mild cognitive impairment (MCI)
  • Physical exercise
  • Yoga

ASJC Scopus subject areas

  • General Neuroscience


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