The junction of twentieth and twenty first centuries is characterized as an age of information. This era is marked by multifaceted colossal advances in information technologies (ITs) [9, 11, 49]. The explosive growth in information technologies is beginning to define not only how we live but also how we think. In this age, progress in many disciplines is primarily determined by how well a discipline can incorporate IT advancements into its own processes. The domain of healthcare is especially well positioned to benefit from ITs. Numerous advances in medical research have fueled explosive growth in the amount of clinical information available to physicians and other health care providers. The new area of Medical Informatics uses ITs to manage clinical information and make it accessible when it is needed to make crucial decisions. Thus, Clinical Decision Support Systems (CDSS) comprise an important aspect of Medical Informatics.