TY - JOUR
T1 - Concise review
T2 - Fat and furious: Harnessing the full potential of adipose-derived stromal vascular fraction
AU - Dykstra, Jordan A.
AU - Facile, Tiffany
AU - Patrick, Ryan J.
AU - Francis, Kevin R.
AU - Milanovich, Samuel
AU - Weimer, Jill M.
AU - Kota, Daniel J.
N1 - Funding Information:
This study was supported by the National Institutes of Health under award numbers R20GM103620, R01NS082283, and P20GM103548.
PY - 2017/4
Y1 - 2017/4
N2 - Due to their capacity to self-renew, proliferate and generate multi-lineage cells, adult-derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer’s disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose-derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose-derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications.
AB - Due to their capacity to self-renew, proliferate and generate multi-lineage cells, adult-derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer’s disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose-derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose-derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications.
KW - Adipose
KW - Adult stem cells
KW - Autologous stem cell transplantation
KW - Cellular therapy
KW - Clinical trials
KW - Mesenchymal stem cells
UR - http://www.scopus.com/inward/record.url?scp=85017532740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017532740&partnerID=8YFLogxK
U2 - 10.1002/sctm.16-0337
DO - 10.1002/sctm.16-0337
M3 - Review article
C2 - 28186685
AN - SCOPUS:85017532740
VL - 6
SP - 1096
EP - 1108
JO - Stem cells translational medicine
JF - Stem cells translational medicine
SN - 2157-6564
IS - 4
ER -