Concise review: Quiescent and active states of endogenous adult neural stem cells: Identification and characterization

Y. A.Zhou Wang, Jennifer M. Plane, Peng Jiang, Chengji J. Zhou, Wenbin Deng

Research output: Contribution to journalShort survey

63 Scopus citations

Abstract

The adult mammalian central nervous system (CNS) lacks the capacity for regeneration, making it a highly sought-after topic for researchers. The identification of neural stem cells (NSCs) in the adult CNS wiped out a long-held dogma that the adult brain contains a set number of neurons and is incapable of replacing them. The discovery of adult NSCs (aNSCs) stoked the fire for researchers who dream of brain self-repair. Unfortunately, the quiescent nature and limited plasticity of aNSCs diminish their regenerative potential. Recent studies evaluating aNSC plasticity under pathological conditions indicate that a switch from quiescent to active aNSCs in neurogenic regions plays an important role in both repairing the damaged tissue and preserving progenitor pools. Here, we summarize the most recent findings and present questions about characterizing the active and quiescent aNSCs in major neurogenic regions, and factors for maintaining their active and quiescent states, hoping to outline an emerging view for promoting the endogenous aNSC-based regeneration.

Original languageEnglish (US)
Pages (from-to)907-912
Number of pages6
JournalSTEM CELLS
Volume29
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Active neural stem cell
  • Differentiation
  • Niche
  • Proliferation
  • Quiescent neural stem cell
  • Regeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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