TY - JOUR
T1 - Concise review
T2 - Recent advances on the significance of stem cells in tissue regeneration and cancer therapies
AU - Mimeault, Murielle
AU - Batra, Surinder K.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - In this study, we report on recent advances on the functions of embryonic, fetal, and adult stem cell progenitors for tissue regeneration and cancer therapies. We describe new procedures for derivation and maturation of these stem cells into the tissue-specific cell progenitors. The localization of the adult stem cells and their niches, as well as their implication in the tissue repair after injuries and during cancer progression, are also described. The emphasis is on the interactions among certain developmental signaling factors, such as hormones, epidermal growth factor, hedgehog, Wnt/β-catenin, and Notch. These factors and their pathways are involved in the stringent regulation of the self-renewal and/or differentiation of adult stem cells. Novel strategies for the treatment of both diverse degenerating disorders, by cell replacement, and some metastatic cancer types, by molecular targeting multiple tumorigenic signaling elements in cancer progenitor cells, are also illustrated.
AB - In this study, we report on recent advances on the functions of embryonic, fetal, and adult stem cell progenitors for tissue regeneration and cancer therapies. We describe new procedures for derivation and maturation of these stem cells into the tissue-specific cell progenitors. The localization of the adult stem cells and their niches, as well as their implication in the tissue repair after injuries and during cancer progression, are also described. The emphasis is on the interactions among certain developmental signaling factors, such as hormones, epidermal growth factor, hedgehog, Wnt/β-catenin, and Notch. These factors and their pathways are involved in the stringent regulation of the self-renewal and/or differentiation of adult stem cells. Novel strategies for the treatment of both diverse degenerating disorders, by cell replacement, and some metastatic cancer types, by molecular targeting multiple tumorigenic signaling elements in cancer progenitor cells, are also illustrated.
KW - Adult stem cells
KW - Embryonic stem cells
KW - Oncogenic transformation
KW - Stem cell-based therapies
KW - Tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=33750592790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750592790&partnerID=8YFLogxK
U2 - 10.1634/stemcells.2006-0066
DO - 10.1634/stemcells.2006-0066
M3 - Short survey
C2 - 16794264
AN - SCOPUS:33750592790
VL - 24
SP - 2319
EP - 2345
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 11
ER -