Constructive antagonism in limb development

Andrew T. Dudley, Clifford J. Tabin

Research output: Contribution to journalReview article

27 Scopus citations


Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of this regulatory program appears to be the precise control of signaling by members of the bone morphogenetic protein family via multiple antagonistic interactions.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number4
StatePublished - Aug 1 2000

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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