Contemporary strategies to improve outcomes for peripheral T-cell lymphoma patients following the failure of first-line therapy

Research output: Contribution to journalReview article

Abstract

Introduction: T cell lymphomas are a heterogeneous group, with varying incidences, geographic patterns, and risk factors. Although until recently approached in a manner similar to B cell lymphomas, the treatment outcomes are poor and this disease is characterized by high relapse rates. The treatment advances in PTCL have been slow compared to B cell lymphomas. The outcomes of patients who progress following stem cell transplantation are worse. Areas covered: This review focuses on the novel targeted agents that are approved and/or are under investigation for patients with relapsed/refractory PTCL. We conducted an electronic literature search of the studies using PubMed, clincaltrials.gov, MEDLINE, using the key words ‘PTCL,’ ‘second line therapy,’ and ‘targeted agents.’ Studies published before January 2020 were included in the search criteria. Expert opinion: Development of newer therapies such as HDAC inhibitors and kinases are promising new agents with activity in relapsed/refractory PTCL. Combination therapy using novel agents may be the future for treatment of PTCL. Therapies in the next few years may take a more personalized approach taking into consideration not just the histology, but also the epigenomic landscape.

Original languageEnglish (US)
Pages (from-to)745-753
Number of pages9
JournalExpert Review of Hematology
Volume13
Issue number7
DOIs
StatePublished - Jul 2 2020

Keywords

  • PTCL
  • T cell lymphoma
  • novel therapies in T cell lymphoma
  • relapsed T cell lymphoma
  • relapsed/refractory T cell lymphoma
  • second line therapy in PTCL

ASJC Scopus subject areas

  • Hematology

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