Continuous infusion of high-dose acyclovir for serious herpesvirus infections

C. V. Fletcher, J. A. Englund, B. Bean, B. Chinnock, D. M. Brundage, H. H. Balfour

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 μmol/liter. Of 12 patients who had continuous infusion for > 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.

Original languageEnglish (US)
Pages (from-to)1375-1378
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume33
Issue number8
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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