Continuous infusion of high-dose acyclovir for serious herpesvirus infections

C. V. Fletcher; J. A. Englund; B. Bean; B. Chinnock; D. M. Brundage; H. H. Balfour

doi:10.1128/AAC.33.8.1375

Continuous infusion of high-dose acyclovir for serious herpesvirus infections

C. V. Fletcher, J. A. Englund, B. Bean, B. Chinnock, D. M. Brundage, H. H. Balfour

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30 Scopus citations

Abstract

Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 μmol/liter. Of 12 patients who had continuous infusion for > 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.

Original language	English (US)
Pages (from-to)	1375-1378
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	33
Issue number	8
DOIs	https://doi.org/10.1128/AAC.33.8.1375
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 μmol/liter. Of 12 patients who had continuous infusion for > 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.",

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AU - Englund, J. A.

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AU - Brundage, D. M.

AU - Balfour, H. H.

PY - 1989

Y1 - 1989

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AB - Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 μmol/liter. Of 12 patients who had continuous infusion for > 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.

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Continuous infusion of high-dose acyclovir for serious herpesvirus infections

Abstract

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