Contrast enhancement using silica microspheres in coherent anti-Stokes Raman spectroscopic imaging

X. Huang, X. N. He, W. Xiong, Y. Gao, L. J. Jiang, L. Liu, Y. S. Zhou, L. Jiang, J. F. Silvain, Y. F. Lu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is a powerful imaging technique that can provide chemical information of organic and nonorganic materials through vibrational spectroscopy. However, its contrast is not sufficient for monitoring thin film materials. In this study, silica microspheres were employed for enhancing the signal contrast in CARS imaging. One layer of optically transparent silica microspheres was self-assembled onto polymer grating samples to enhance the CARS signals. The highest contrast enhancement factor of 12.5 was achieved using 6.1-μm-diameter microspheres. Finite-difference timedomain method (FDTD) simulation was conducted to simulate the contrast enhancement with silica microspheres of different diameters.

Original languageEnglish (US)
Pages (from-to)2889-2896
Number of pages8
JournalOptics Express
Volume22
Issue number3
DOIs
StatePublished - Feb 10 2014

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Huang, X., He, X. N., Xiong, W., Gao, Y., Jiang, L. J., Liu, L., Zhou, Y. S., Jiang, L., Silvain, J. F., & Lu, Y. F. (2014). Contrast enhancement using silica microspheres in coherent anti-Stokes Raman spectroscopic imaging. Optics Express, 22(3), 2889-2896. https://doi.org/10.1364/OE.22.002889