Abstract
Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become "weapons of mass destruction," causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.
Original language | English (US) |
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Pages (from-to) | 110-123 |
Number of pages | 14 |
Journal | Biological Communications |
Volume | 64 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2019 |
Keywords
- Cancer
- Cytosine deaminases AID/APOBEC
- DNA damage
- Mutation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)