Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

Irina Zotova; Elena Stepchenkova; Youri Pavlov

doi:10.21638/spbu03.2019.203

Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

Irina Zotova, Elena Stepchenkova, Youri Pavlov

Research output: Contribution to journal › Review article › peer-review

Abstract

Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become "weapons of mass destruction," causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.

Original language	English (US)
Pages (from-to)	110-123
Number of pages	14
Journal	Biological Communications
Volume	64
Issue number	2
DOIs	https://doi.org/10.21638/spbu03.2019.203
State	Published - Jun 2019

Keywords

Cancer
Cytosine deaminases AID/APOBEC
DNA damage
Mutation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

Access to Document

10.21638/spbu03.2019.203

Cite this

@article{f4f5e309680f4ddab721b09e9021a543,

title = "Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis",

abstract = "Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become {"}weapons of mass destruction,{"} causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.",

keywords = "Cancer, Cytosine deaminases AID/APOBEC, DNA damage, Mutation",

author = "Irina Zotova and Elena Stepchenkova and Youri Pavlov",

note = "Publisher Copyright: {\textcopyright} 2019 Zotova et al.",

year = "2019",

month = jun,

doi = "10.21638/spbu03.2019.203",

language = "English (US)",

volume = "64",

pages = "110--123",

journal = "Biological Communications",

issn = "2542-2154",

publisher = "Saint Petersburg State University",

number = "2",

}

TY - JOUR

T1 - Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

AU - Zotova, Irina

AU - Stepchenkova, Elena

AU - Pavlov, Youri

PY - 2019/6

Y1 - 2019/6

N2 - Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become "weapons of mass destruction," causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.

AB - Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become "weapons of mass destruction," causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.

KW - Cancer

KW - Cytosine deaminases AID/APOBEC

KW - DNA damage

KW - Mutation

UR - http://www.scopus.com/inward/record.url?scp=85085130325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085130325&partnerID=8YFLogxK

U2 - 10.21638/spbu03.2019.203

DO - 10.21638/spbu03.2019.203

M3 - Review article

AN - SCOPUS:85085130325

SN - 2542-2154

VL - 64

SP - 110

EP - 123

JO - Biological Communications

JF - Biological Communications

IS - 2

ER -

Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this