Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis

Irina Zotova, Elena Stepchenkova, Youri Pavlov

Research output: Contribution to journalReview article

Abstract

Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become "weapons of mass destruction," causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism's defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.

Original languageEnglish (US)
Pages (from-to)110-123
Number of pages14
JournalBiological Communications
Volume64
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • Cancer
  • Cytosine deaminases AID/APOBEC
  • DNA damage
  • Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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