Contribution of hiatal hernia to asthma in patients with gastroesophageal reflux disease

Zhi Tong Li, Feng Ji, Xin Wei Han, Lin Xia Gu, Li Wang, Yong Qiang Yue, Zhong Gao Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: To determine the correlation between asthma and hiatal hernia (HH) in patients with gastroesophageal reflux disease (GERD)-related asthma requiring laparoscopic anti-reflux surgery. Methods: One hundred and thirty-six GERD patients with medically refractory asthma with (80 patients) or without HH (56 patients) were enrolled. Gastroesophageal reflux disease was assessed by endoscopy, esophageal manometry, reflux monitoring and symptom questionnaires, and treated with laparoscopic Nissen fundoplication (LNF) or LNF with concomitant hiatal hernia repair (LNF-HHR). The outcome measures included patients' satisfaction and drug independence. Results: The patients with HH had lower esophageal sphincters (P =.005) and higher DeMeester scores (P =.014) than those without HH. After an average follow-up of 24 months, symptom scores were significantly decreased from the preoperative values (P <.05). Compared to LNF, LNF-HHR showed a better improvement in both esophageal and asthmatic symptoms (P <.0001 and P =.016, respectively). Conclusions: The patients with GERD with asthma have a high prevalence of HH. The presence of HH maybe correlated with asthma and severe GERD. Actively treating HH not only improved reflux, but also controlled asthma symptoms.

Original languageEnglish (US)
Pages (from-to)1858-1864
Number of pages7
JournalClinical Respiratory Journal
Issue number5
StatePublished - May 2018


  • asthma
  • fundoplication
  • gastroesophageal reflux disease
  • hernia repair
  • hiatal hernia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Genetics(clinical)


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