Control of pharmacokinetic profiles of drug-macromolecule conjugates

Yoshinobu Takakura, Ram I. Mahato, Makiya Nishikawa, Mitsuru Hashida

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

Macromolecular conjugation is a useful method for controlling the pharmacokinetic profiles of small drugs, proteins, oligonucleotides and genes. Site-specific drug delivery can be achieved by the use of an appropriate macromolecular carrier which should have an affinity for the target tissue or cells. The rationale of this approach is to alter the disposition characteristics of a free drug by conjugating it to a suitable macromolecular carrier. The rational design of drug-macromolecule conjugates requires a thorough understanding of the relationship between their chemical structures, physicochemical properties and pharmacokinetics at whole body, organ, cellular and subcellular levels. In this article, the current status and future perspectives of macromolecular conjugates of conventional low molecular weight drugs, protein drugs and gene medicines, such as antisense oligonucleotides and plasmid DNA, are reviewed.

Original languageEnglish (US)
Pages (from-to)377-399
Number of pages23
JournalAdvanced Drug Delivery Reviews
Volume19
Issue number3
DOIs
StatePublished - Jun 12 1996
Externally publishedYes

Keywords

  • Antitumor drugs
  • DNA drugs
  • Macromolecular conjugate
  • Pharmacokinetics
  • Protein drugs
  • Targeting

ASJC Scopus subject areas

  • Pharmaceutical Science

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