Control of the autoimmune response by type 2 nitric oxide synthase

F. D. Shi, M. Flodström, Ha Kim Soon Ha Kim, S. Pakala, M. Cleary, H. G. Ljunggren, N. Sarvetnick

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Immune defense against pathogens often requires NO, synthesized by type 2 NO synthase (NOS2). To discern whether this axis could participate in an autoimmune response, we immunized NOS2-deficient mice with the autoantigen acetylcholine receptor, inducing muscle weakness characteristic of myasthenia gravis, a T cell-dependent Ab-mediated autoimmune disease. We found that the acetylcholine receptor-immunized NOS2-deficient mice developed an exacerbated form of myasthenia gravis, and demonstrated that NOS2 expression limits autoreactive T cell determinant spreading and diversification of the autoantibody repertoire, a process driven by macrophages. Thus, NOS2/NO is important for silencing autoreactive T cells and may restrict bystander autoimmune reactions following the innate immune response.

Original languageEnglish (US)
Pages (from-to)3000-3006
Number of pages7
JournalJournal of Immunology
Issue number5
StatePublished - Sep 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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