Control of the renal microvasculature by vasoactive peptides

P. K. Carmines, J. T. Fleming

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


In recent years, numerous techniques have been developed to study renal microcirculation. These technical advances have provided new insight regarding the specificity of action of vasoconstrictor peptides (angiotensin II, arginine vasopressin, endothelin) and vasodilator peptides (bradykinin, atrial natriuretic peptide) at discrete sites within the renal vascular bed. Differential signal transduction mechanisms, particularly those related to calcium regulation, appear to mediate the renal vascular actions of these compounds, both in a segment-specific and agonist-specific manner. These observations substantiate the concept that regulation of intrarenal and intraglomerular dynamics is accomplished by selective changes in pre- and postglomerular resistance induced by different endogenous peptides. This microvascular selectivity allows precise regulation of glomerular and peritubular capillary function, and ultimately exerts great influence on the volume and composition of the final urine.

Original languageEnglish (US)
Pages (from-to)3300-3309
Number of pages10
JournalFASEB Journal
Issue number15
StatePublished - 1990
Externally publishedYes


  • Angiotensin II
  • Arginine vasopressin
  • Atrial natriuretic peptide
  • Bradykinin
  • Calcium
  • Endothelin
  • Renal microcirculation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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