Controlled release formulation of ranitidine-containing montmorillonite and Eudragit® E-100

Ghanshyam V. Joshi, Bhavesh D. Kevadiya, Hari C. Bajaj

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Aim: The objective of this work was to illustrate the suitability of montmorillonite (MMT) as a drug delivery carrier, by developing a new claydrug composite of ranitidine hydrochloride (RT) intercalated in MMT. Methods: The MMTRT composite was prepared by ion-exchange process. X-ray diffraction and Fourier transform infrared spectra were employed to confirm the intercalation of RT in the MMT interlayers. The prepared MMTRT hybrid was coated with cationic polymer Eudragit® E-100 by oil-in-water solvent evaporation method. The release processes of RT from MMTRT and MMTRTEudragit® E-100 were monitored under in vitro condition in the gastric fluid. Results: X-ray diffraction and Fourier transform infrared spectra analysis indicated the intercalation of RT molecules within the clay lattice. The in vitro release studies showed that MMTRT released RT in a controlled manner. In the case of MMTRTEudragit® E-100, both the release rate and the release percentages noticeably increased in the presence of Eudragit® E-100, because of its effective exchange with intercalated RT molecules. The release kinetics followed parabolic diffusion mechanism. Conclusion: MMT has great potential as a drug delivery carrier with various scenarios. The dosage of the MMTRTEudragit® E-100 can be in the tablet form. The hybrid material and polymer-coated hybrids are microparticles.

Original languageEnglish (US)
Pages (from-to)1046-1053
Number of pages8
JournalDrug Development and Industrial Pharmacy
Volume36
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Controlled release
  • Eudragit®E-100
  • Intercalation
  • Kinetics
  • Montmorillonite
  • Ranitidine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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