Controlled transscleral drug delivery formulations to the eye: Establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis

Fernando Paganelli, José A. Cardillo, Alessandro R.J. Dare, Luiz A.S. Melo, David R. Lucena, Arnobio A. Silva, Anselmo G. Oliveira, Antonio C. Pizzolitto, Daniel Lavinsky, Mirian Skaf, Accio A. Souza-Filho, Ana L. Hfling-Lima, Quan Dong Nguyen, Baruch D. Kuppermann, Rocio Herrero-Vanrell, Rubens Belfort

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Importance of the field: The use of topical agents poses unique and challenging hurdles for drug delivery. Topical steroids effectively control ocular inflammation, but are associated with the well-recognized dilemma of patient compliance. Although administration of topical antimicrobials as prophylaxis is acceptable among ophthalmologists, this common practice has no sound evidence base. Developing a new antimicrobial agent or delivery strategy with enhanced penetration by considering the anatomical and physiological constraints exerted by the barriers of the eye is not a commonly perceived strategy. Exploiting the permeability of the sclera, subconjunctival routes may offer a promising alternative for enhanced drug delivery and tissue targeting. Area covered in this review: Ocular drug delivery strategies were reviewed for ocular inflammation and infections clinically adopted for newer class of antimicrobials, which use a multipronged approach to limit risks of endophthalmitis. What the reader will gain: The analysis substantiates a new transscleral drug delivery therapeutic approach for cataract surgery. Take home message: A new anti-inflammatory and anti-infective paradigm that frees the patient from the nuisance of topical therapeutics is introduced, opening a large investigative avenue for future improved therapies.

Original languageEnglish (US)
Pages (from-to)955-965
Number of pages11
JournalExpert Opinion on Drug Delivery
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Keywords

  • Antibiotics
  • Antimicrobials
  • Cataract surgery
  • Endophthalmitis
  • Eye drops
  • Eye infections
  • Intraocular penetration
  • Ocular drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Paganelli, F., Cardillo, J. A., Dare, A. R. J., Melo, L. A. S., Lucena, D. R., Silva, A. A., Oliveira, A. G., Pizzolitto, A. C., Lavinsky, D., Skaf, M., Souza-Filho, A. A., Hfling-Lima, A. L., Nguyen, Q. D., Kuppermann, B. D., Herrero-Vanrell, R., & Belfort, R. (2010). Controlled transscleral drug delivery formulations to the eye: Establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis. Expert Opinion on Drug Delivery, 7(8), 955-965. https://doi.org/10.1517/17425247.2010.498817