TY - JOUR
T1 - Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma
AU - Bernal, Giovanna M.
AU - LaRiviere, Michael J.
AU - Mansour, Nassir
AU - Pytel, Peter
AU - Cahill, Kirk E.
AU - Voce, David J.
AU - Kang, Shijun
AU - Spretz, Ruben
AU - Welp, Ulrich
AU - Noriega, Sandra E.
AU - Nuñez, Luis
AU - Larsen, Gustavo
AU - Weichselbaum, Ralph R.
AU - Yamini, Bakhtiar
PY - 2014/1
Y1 - 2014/1
N2 - A major obstacle to the management of malignant glioma is the inability to effectively deliver therapeutic agent to the tumor. In this study, we describe a polymeric nanoparticle vector that not only delivers viable therapeutic, but can also be tracked in vivo using MRI. Nanoparticles, produced by a non-emulsion technique, were fabricated to carry iron oxide within the shell and the chemotherapeutic agent, temozolomide (TMZ), as the payload. Nanoparticle properties were characterized and subsequently their endocytosis-mediated uptake by glioma cells was demonstrated. Convection-enhanced delivery (CED) can disperse nanoparticles through the rodent brain and their distribution is accurately visualized by MRI. Infusion of nanoparticles does not result in observable animal toxicity relative to control. CED of TMZ-bearing nanoparticles prolongs the survival of animals with intracranial xenografts compared to control. In conclusion, the described nanoparticle vector represents a unique multifunctional platform that can be used for image-guided treatment of malignant glioma. From the Clinical Editor: GBM remains one of the most notoriously treatment-unresponsive cancer types. In this study, a multifunctional nanoparticle-based temozolomide delivery system was demonstrated to possess enhanced treatment efficacy in a rodent xenograft GBM model, with the added benefit of MRI-based tracking via the incorporation of iron oxide as a T2* contrast material in the nanoparticles.
AB - A major obstacle to the management of malignant glioma is the inability to effectively deliver therapeutic agent to the tumor. In this study, we describe a polymeric nanoparticle vector that not only delivers viable therapeutic, but can also be tracked in vivo using MRI. Nanoparticles, produced by a non-emulsion technique, were fabricated to carry iron oxide within the shell and the chemotherapeutic agent, temozolomide (TMZ), as the payload. Nanoparticle properties were characterized and subsequently their endocytosis-mediated uptake by glioma cells was demonstrated. Convection-enhanced delivery (CED) can disperse nanoparticles through the rodent brain and their distribution is accurately visualized by MRI. Infusion of nanoparticles does not result in observable animal toxicity relative to control. CED of TMZ-bearing nanoparticles prolongs the survival of animals with intracranial xenografts compared to control. In conclusion, the described nanoparticle vector represents a unique multifunctional platform that can be used for image-guided treatment of malignant glioma. From the Clinical Editor: GBM remains one of the most notoriously treatment-unresponsive cancer types. In this study, a multifunctional nanoparticle-based temozolomide delivery system was demonstrated to possess enhanced treatment efficacy in a rodent xenograft GBM model, with the added benefit of MRI-based tracking via the incorporation of iron oxide as a T2* contrast material in the nanoparticles.
KW - Convection
KW - Glioma
KW - MRI
KW - Nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=84891016613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891016613&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2013.07.003
DO - 10.1016/j.nano.2013.07.003
M3 - Article
C2 - 23891990
AN - SCOPUS:84891016613
SN - 1549-9634
VL - 10
SP - 149
EP - 157
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 1
ER -