Conversion of the lymphoma line “BJAB” by Epstein‐Barr virus into phenotypically altered sublines is accompanied by increased C‐myc mRNA levels

Anders Wennborg, Pierre Åman, Dhananjaya Saranath, Warren Pear, Janos Sümegi, George Klein

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The steady‐state level of c‐myc proto‐oncogene mRNA was investigated in the EBV‐negative human B‐lymphoma line BJAB and 2 sublines that have been converted by EBV into stable EBV‐genome‐carrying and EBNA‐positive status. The EBV‐converted sublines expressed c‐myc at a 2‐to 6‐fold higher level than the original BJAB during exponential growth. The EBV‐positive BJAB lines are known to differ from the parent line in several phenotypic characteristics, including increased agarose clonability, lower serum requirements and, in one case, increased tumorigenicity in nude mice. The pattern of increased c‐myc expression accompanying EBV conversion was not observed in the myc/lg translocation‐carrying Burkitt lymphoma line RAMOS or in 2 of its EBV‐converted sublines.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalInternational Journal of Cancer
Volume40
Issue number2
DOIs
StatePublished - Aug 15 1987

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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