Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn2+ pumps

Marc J. Gallenito, Gordon W. Irvine, Limei Zhang, Gabriele Meloni

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Metal selectivity in P1B-type ATPase pumps appears to be determined by amino acid motifs on their transmembrane helices. We reveal the principles governing substrate promiscuity towards first-, second- and third-row transition metals in a transmembrane Zn2+/Cd2+/Hg2+/Pb2+ P-type ATPase (ZntA), by dissecting its coordination chemistry. Atomic resolution characterization in detergent micelles and lipid bilayers reveals a "plastic" transmembrane metal-binding site that selects substrates by unique and diverse, yet defined, coordination geometries and ligand-metal distances.

Original languageEnglish (US)
Pages (from-to)10844-10847
Number of pages4
JournalChemical Communications
Volume55
Issue number73
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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