Correlation of end-tidal CO2 to cerebral perfusion during CPR

Lawrence M. Lewis, Joseph Stothert, John Standeven, Bhugol Chandel, Michael Kurtz, John Fortney

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Study objective: A number of studies have demonstrated a correlation between end-tidal carbon dioxide (ETco2), cardiac output, and return of spontaneous circulation in experimental animals and in patients undergoing closed-chest CPR. Our study attempted to correlate ETco2 to cerebral blood flow during cardiac arrest. Design: Sixteen piglets were anesthetized, intubated, and instrumented for cerebral blood flow studies. An ultrasonic flow probe was placed on both internal carotid arteries for continuous flow measurements. The animal was fibrillated, and closed-chest CPR was begun. Continuous ETc02 measurements were obtained and compared with simultaneous internal carotid, cardiac output, and cerebral blood flow measurements. Measurements and main results: Correlations between ETco2 and carotid and cerebral blood flow were determined using Pearson's method. The correlation between ETco2 and total internal carotid flow was .58 (P = .01, Bonferroni's adjusted P = .30). Correlation between ETco2 and cerebral blood flow was .64 (P = .01, Bonferroni's adjusted P = .09). A partial correlation coefficient for ETco2 versus cardiac output was .70, whereas it was only .30 for ETco2 versus cerebral blood flow. Conclusion: Partial correlation coefficients suggest that ETco2 correlates with cerebral blood flow when changes in cerebral blood flow parallel changes in cardiac output.

Original languageEnglish (US)
Pages (from-to)1131-1134
Number of pages4
JournalAnnals of emergency medicine
Issue number9
StatePublished - Sep 1992
Externally publishedYes


  • CPR
  • cerebral perfusion
  • end-tidal CO

ASJC Scopus subject areas

  • Emergency Medicine


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