Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

C. H. Pui, D. L. Williams, P. K. Roberson, S. C. Raimondi, F. G. Behm, S. H. Lewis, G. K. Rivera, D. K. Kalwinsky, M. Abromowitch, W. M. Crist, S. B. Murphy

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy >50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA+) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P<.001), and none of the B cell cases (P<.001) or cases of CALLA negative (CALLA-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA+ early pre-B ALL cases (35%) than in B cell (100%; P<.0001), pre-B (59%; P<.001), or CALLA- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalJournal of Clinical Oncology
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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