Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

C. H. Pui; D. L. Williams; P. K. Roberson; S. C. Raimondi; F. G. Behm; S. H. Lewis; G. K. Rivera; D. K. Kalwinsky; M. Abromowitch; W. M. Crist; S. B. Murphy

doi:10.1200/JCO.1988.6.1.56

Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

C. H. Pui, D. L. Williams, P. K. Roberson, S. C. Raimondi, F. G. Behm, S. H. Lewis, G. K. Rivera, D. K. Kalwinsky, M. Abromowitch, W. M. Crist, S. B. Murphy

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy >50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA⁺) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P<.001), and none of the B cell cases (P<.001) or cases of CALLA negative (CALLA^-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA⁺ early pre-B ALL cases (35%) than in B cell (100%; P<.0001), pre-B (59%; P<.001), or CALLA^- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.

Original language	English (US)
Pages (from-to)	56-61
Number of pages	6
Journal	Journal of Clinical Oncology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1200/JCO.1988.6.1.56
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1200/JCO.1988.6.1.56

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@article{61b33973780f43bea22d7683ba3d8852,

title = "Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia",

abstract = "To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy >50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA+) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P<.001), and none of the B cell cases (P<.001) or cases of CALLA negative (CALLA-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA+ early pre-B ALL cases (35%) than in B cell (100%; P<.0001), pre-B (59%; P<.001), or CALLA- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.",

author = "Pui, {C. H.} and Williams, {D. L.} and Roberson, {P. K.} and Raimondi, {S. C.} and Behm, {F. G.} and Lewis, {S. H.} and Rivera, {G. K.} and Kalwinsky, {D. K.} and M. Abromowitch and Crist, {W. M.} and Murphy, {S. B.}",

year = "1988",

doi = "10.1200/JCO.1988.6.1.56",

language = "English (US)",

volume = "6",

pages = "56--61",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

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TY - JOUR

T1 - Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

AU - Pui, C. H.

AU - Williams, D. L.

AU - Roberson, P. K.

AU - Raimondi, S. C.

AU - Behm, F. G.

AU - Lewis, S. H.

AU - Rivera, G. K.

AU - Kalwinsky, D. K.

AU - Abromowitch, M.

AU - Crist, W. M.

AU - Murphy, S. B.

PY - 1988

Y1 - 1988

N2 - To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy >50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA+) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P<.001), and none of the B cell cases (P<.001) or cases of CALLA negative (CALLA-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA+ early pre-B ALL cases (35%) than in B cell (100%; P<.0001), pre-B (59%; P<.001), or CALLA- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.

AB - To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy >50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA+) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P<.001), and none of the B cell cases (P<.001) or cases of CALLA negative (CALLA-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA+ early pre-B ALL cases (35%) than in B cell (100%; P<.0001), pre-B (59%; P<.001), or CALLA- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.

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Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

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