Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease

Lindsay J. Hines, Eric N. Miller, Charles H. Hinkin, Jeffery R. Alger, Peter Barker, Karl Goodkin, Eileen M. Martin, Victoria Maruca, Ann Ragin, Ned Sacktor, Joanne Sanders, Ola Selnes, James T. Becker, the Multicenter AIDS Cohort Study for the Multicenter AIDS Cohort Study

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

To characterize the relationship between dispersion-based intra-individual variability (IIVd) in neuropsychological test performance and brain volume among HIV seropositive and seronegative men and to determine the effects of cardiovascular risk and HIV infection on this relationship. Magnetic Resonance Imaging (MRI) was used to acquire high-resolution neuroanatomic data from 147 men age 50 and over, including 80 HIV seropositive (HIV+) and 67 seronegative controls (HIV-) in this cross-sectional cohort study. Voxel Based Morphometry was used to derive volumetric measurements at the level of the individual voxel. These brain structure maps were analyzed using Statistical Parametric Mapping (SPM2). IIVd was measured by computing intra-individual standard deviations (ISD’s) from the standardized performance scores of five neuropsychological tests: Wechsler Memory Scale-III Visual Reproduction I and II, Logical Memory I and II, Wechsler Adult Intelligence Scale-III Letter Number Sequencing. Total gray matter (GM) volume was inversely associated with IIVd. Among all subjects, IIVd -related GM atrophy was observed primarily in: 1) the inferior frontal gyrus bilaterally, the left inferior temporal gyrus extending to the supramarginal gyrus, spanning the lateral sulcus; 2) the right superior parietal lobule and intraparietal sulcus; and, 3) dorsal/ventral regions of the posterior section of the transverse temporal gyrus. HIV status, biological, and cardiovascular disease (CVD) variables were not linked to IIVd -related GM atrophy. IIVd in neuropsychological test performance may be a sensitive marker of cortical integrity in older adults, regardless of HIV infection status or CVD risk factors, and degree of intra-individual variability links with volume loss in specific cortical regions; independent of mean-level performance on neuropsychological tests.

Original languageEnglish (US)
Pages (from-to)640-651
Number of pages12
JournalBrain Imaging and Behavior
Volume10
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • Cognition
  • HIV
  • Imaging
  • Intra-individual variability
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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    Hines, L. J., Miller, E. N., Hinkin, C. H., Alger, J. R., Barker, P., Goodkin, K., Martin, E. M., Maruca, V., Ragin, A., Sacktor, N., Sanders, J., Selnes, O., Becker, J. T., & for the Multicenter AIDS Cohort Study, T. M. AIDS. C. S. (2016). Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease. Brain Imaging and Behavior, 10(3), 640-651. https://doi.org/10.1007/s11682-015-9441-1