Costimulatory blockade with belatacept in clinical and experimental transplantation - A review

Juliet Emamaullee, Christian Toso, Shaheed Merani, A. M.James Shapiro

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Background: Current maintenance immunosuppression agents have been critical to the improved graft and patient survival rates in solid organ transplantation observed over the past decade. However, long-term follow-up has revealed that these agents are associated with troublesome side effects and chronic toxicity, contributing to graft loss and death. Objectives: Costimulation blockade has long been recognized as an important target for immunomodulation in solid organ transplantation. Belatacept, a high-affinity chimeric fusion protein that binds to CD80/CD86 on antigen-presenting cells, has shown great promise in renal transplantation and is now in Phase III trials. Methods: This review explores the development and efficacy of belatacept, compared with currently approved immunosuppressive agents used in transplantation. Results: Belatacept seems to be an effective alternative to current maintenance immunosuppressive therapies, with no apparent end organ toxicity and a minimal side-effect profile. This agent works best when used in combination with therapies that target different pathways of T-cell activation, but the optimal regimen has not yet been identified. Data generated in ongoing clinical trials will be essential in validating previous studies and for further development of belatacept-based combinatorial strategies.

Original languageEnglish (US)
Pages (from-to)789-796
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume9
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Abatacept
  • Belatacept
  • Costimulation blockade
  • Immunosuppression
  • Organ transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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