Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?

Eduardo Mansilla, Vanina Díaz Aquino, Daniel Zambn, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H. Riordan, Amit Patel, Flavio Sturla, Gustavo Larsen, Rubén Spretz, Luis Nez, Carlos Soratti, Ricardo Ibar, Michiel Van Leeuwen, José María Tau, Hugo Drago, Alberto MacEira

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.

Original languageEnglish (US)
Article number943216
JournalStem Cells International
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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