County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels

S. Cristina Oancea; Bradley C. Rundquist; Isaac Simon; Sami Swartz; Yun Zheng; Xudong Zhou; Mary Ann Sens; Gary G. Schwartz

doi:10.2217/fon-2017-0165

County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels

S. Cristina Oancea, Bradley C. Rundquist, Isaac Simon, Sami Swartz, Yun Zheng, Xudong Zhou, Mary Ann Sens, Gary G. Schwartz

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aim: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. Methods: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. Results: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). Conclusion: CLL is significantly associated with RR at the county level.

Original language	English (US)
Pages (from-to)	1873-1881
Number of pages	9
Journal	Future Oncology
Volume	13
Issue number	21
DOIs	https://doi.org/10.2217/fon-2017-0165
State	Published - Sep 2017
Externally published	Yes

Keywords

chronic lymphocytic leukemia
epidemiology
ionizing radiation
latitude
radon

ASJC Scopus subject areas

Oncology
Cancer Research

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@article{6a70f3481ebd43e3b2ec124970f1b744,

title = "County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels",

abstract = "Aim: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. Methods: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. Results: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). Conclusion: CLL is significantly associated with RR at the county level.",

keywords = "chronic lymphocytic leukemia, epidemiology, ionizing radiation, latitude, radon",

author = "Oancea, {S. Cristina} and Rundquist, {Bradley C.} and Isaac Simon and Sami Swartz and Yun Zheng and Xudong Zhou and Sens, {Mary Ann} and Schwartz, {Gary G.}",

note = "Funding Information: Research reported in this publication was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103442. Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = sep,

doi = "10.2217/fon-2017-0165",

language = "English (US)",

volume = "13",

pages = "1873--1881",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Future Medicine Ltd.",

number = "21",

}

TY - JOUR

T1 - County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels

AU - Oancea, S. Cristina

AU - Rundquist, Bradley C.

AU - Simon, Isaac

AU - Swartz, Sami

AU - Zheng, Yun

AU - Zhou, Xudong

AU - Sens, Mary Ann

AU - Schwartz, Gary G.

N1 - Funding Information: Research reported in this publication was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103442. Publisher Copyright: © 2017 Future Medicine Ltd.

PY - 2017/9

Y1 - 2017/9

N2 - Aim: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. Methods: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. Results: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). Conclusion: CLL is significantly associated with RR at the county level.

AB - Aim: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. Methods: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. Results: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). Conclusion: CLL is significantly associated with RR at the county level.

KW - chronic lymphocytic leukemia

KW - epidemiology

KW - ionizing radiation

KW - latitude

KW - radon

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SN - 1479-6694

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EP - 1881

JO - Future Oncology

JF - Future Oncology

IS - 21

ER -

County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels

Abstract

Keywords

ASJC Scopus subject areas

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