Covalent reinforcement of hydrogen-bonded discs into stably folded helical structures

Zhongzhu Chen, Nathaniel D. Urban, Yi Gao, Wenrui Zhang, Jingen Deng, Jin Zhu, Xiao Cheng Zeng, Bing Gong

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The presence of covalent tethers significantly enhanced the stability of structures consisting of helically arranged benzenetricarboxamide units that otherwise undergo very weak hydrogen-bonding interaction. The resultant molecular structures were probed by computational study, which predicted folded conformations consisting of helically arranged discs. Experimental studies confirmed the H-bonding interaction between the disk units, the monomeric nature of the corresponding molecules in solution, and the helical conformations of such molecules.

Original languageEnglish (US)
Pages (from-to)4008-4011
Number of pages4
JournalOrganic Letters
Issue number15
StatePublished - Aug 5 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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