COVID-19 Vaccines and SARS-CoV-2 Transmission in the Era of New Variants: A Review and Perspective

Jasmine R. Marcelin, Audrey Pettifor, Holly Janes, Elizabeth R. Brown, James G. Kublin, Kathryn E. Stephenson

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Coronavirus disease 2019 (COVID-19) vaccines have yielded definitive prevention and major reductions in morbidity and mortality from severe acute respiratory syndrome coronavirus 2 infection, even in the context of emerging and persistent variants of concern. Newer variants have revealed less vaccine protection against infection and attenuation of vaccine effects on transmission. COVID-19 vaccines still likely reduce transmission compared with not being vaccinated at all, even with variants of concern; however, determining the magnitude of transmission reduction is constrained by the challenges of performing these studies, requiring accurate linkage of infections to vaccine status and timing thereof, particularly within households. In this review, we synthesize the currently available data on the impact of COVID-19 vaccines on infection, serious illness, and transmission; we also identify the challenges and opportunities associated with policy development based on this data.

Original languageEnglish (US)
Article numberofac124
JournalOpen Forum Infectious Diseases
Issue number5
StatePublished - May 1 2022


  • Asymptomatic infection
  • COVID-19
  • SARS-CoV-2
  • Transmission
  • Variants
  • Viral shedding

ASJC Scopus subject areas

  • Oncology
  • Infectious Diseases


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