Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

S. Tracy; Nora M. Chapman; Z. Tu

doi:10.1007/BF01317202

Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

S. Tracy, Nora M. Chapman, Z. Tu

Pathology & Microbiology

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56 Scopus citations

Abstract

A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

Original language	English (US)
Pages (from-to)	399-409
Number of pages	11
Journal	Archives of Virology
Volume	122
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01317202
State	Published - Sep 1992

ASJC Scopus subject areas

Virology

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10.1007/BF01317202

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title = "Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice",

abstract = "A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.",

author = "S. Tracy and Chapman, {Nora M.} and Z. Tu",

year = "1992",

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AU - Tracy, S.

AU - Chapman, Nora M.

AU - Tu, Z.

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N2 - A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

AB - A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

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Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

Abstract

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