CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

Caroline L. Ng, Giulia Siciliano, Marcus C.S. Lee, Mariana J. de Almeida, Victoria C. Corey, Selina E. Bopp, Lucia Bertuccini, Sergio Wittlin, Rachel G. Kasdin, Amélie Le Bihan, Martine Clozel, Elizabeth A. Winzeler, Pietro Alano, David A. Fidock

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Medicine & Life Sciences