CRISPR/Cas9 and the paradigm shift in mouse genome manipulation technologies

Channabasavaiah B. Gurumurthy, Rolen M. Quadros, Masahiro Sato, Tomoji Mashimo, K. C.Kent Lloyd, Masato Ohtsuka

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


The CRISPR revolution that began in 2013 has been adopted and embraced by many researchers worldwide, including the mouse molecular genetics community. CRISPR represents one of only a few radical and transformative shifts in transgenic technologies over the past 30 years. This chapter discusses the paradigm shift that CRISPR technology has brought about in the field of mouse genome editing.

Original languageEnglish (US)
Title of host publicationGenome Editing
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783319341484
ISBN (Print)9783319341460
StatePublished - Jan 1 2016


  • CRISPR/Cas9
  • Genome editing
  • Knock-in
  • Knockout
  • Microinjection
  • Mouse genome
  • Transgenic

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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