CRISPR/Cas9 and the paradigm shift in mouse genome manipulation technologies

Channabasavaiah B. Gurumurthy; Rolen M. Quadros; Masahiro Sato; Tomoji Mashimo; K. C.Kent Lloyd; Masato Ohtsuka

doi:10.1007/978-3-319-34148-4_4

CRISPR/Cas9 and the paradigm shift in mouse genome manipulation technologies

Channabasavaiah B. Gurumurthy, Rolen M. Quadros, Masahiro Sato, Tomoji Mashimo, K. C.Kent Lloyd, Masato Ohtsuka

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Abstract

The CRISPR revolution that began in 2013 has been adopted and embraced by many researchers worldwide, including the mouse molecular genetics community. CRISPR represents one of only a few radical and transformative shifts in transgenic technologies over the past 30 years. This chapter discusses the paradigm shift that CRISPR technology has brought about in the field of mouse genome editing.

Original language	English (US)
Title of host publication	Genome Editing
Publisher	Springer International Publishing
Pages	65-77
Number of pages	13
ISBN (Electronic)	9783319341484
ISBN (Print)	9783319341460
DOIs	https://doi.org/10.1007/978-3-319-34148-4_4
State	Published - Jan 1 2016

Keywords

CRISPR/Cas9
Genome editing
Knock-in
Knockout
Microinjection
Mouse genome
Transgenic

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1007/978-3-319-34148-4_4

Cite this

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AU - Sato, Masahiro

AU - Mashimo, Tomoji

AU - Lloyd, K. C.Kent

AU - Ohtsuka, Masato

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CRISPR/Cas9 and the paradigm shift in mouse genome manipulation technologies

Abstract

Keywords

ASJC Scopus subject areas

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