Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis

Guodong Ren, Bin Yu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate and/or efficient processing of precursors of miRNAs. Many of these RNA-binding proteins also have roles in general RNA metabolism, indicating potential connections between miRNA biogenesis and other RNA metabolism. Here, we focus on the function of several RNAbinding proteins in miRNA biogenesis in Arabidopsis.

Original languageEnglish (US)
Pages (from-to)1424-1428
Number of pages5
JournalRNA Biology
Volume9
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Arabidopsis
  • CBP80/CBP20
  • DCL1
  • DDL
  • HYL1
  • RNA-binding protein
  • SE
  • TOUGH
  • miRNA biogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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