TY - JOUR
T1 - Cross-linked polymeric micelles based on block ionomer complexes
AU - Kim, Jong Oh
AU - Ramasamy, Thiruganesh
AU - Yong, Chul Soon
AU - Nukolov, Natalia V.
AU - Bronich, Tatiana K.
AU - Kabanov, Alexander V.
N1 - Funding Information:
This work was supported by the US National Science Foundation [grant nos. DMR0513699 and DMR0071682 (AVK)], the US National Institutes of Health [grant nos. 1R01CA116590 (TKB) and 1P20RR021937 (AVK/TB)], the US Department of Defense [grant no. USAMRMC 06108004 (AVK)] and the Government of the Russian Federation [grant no. 11.G34.31.0004 (AVK)]. We are grateful to Dr. D.Y. Filonova (Alakhova) for her assistance in the preparation of illustration for this paper.
PY - 2013/7
Y1 - 2013/7
N2 - Polymeric micelles formed as a result of the self-assembly of block copolymers constitute an important class of supramolecular structures that attracted attention as drug carriers in drug delivery and nanomedicine. Chemical stabilization of the polymeric micelles by introducing cross-links between block copolymer chains can increase stability and prevent premature disintegration of these micelles in the body. The cross-linking strategy has been also applied to a special class of polymeric micelles formed by block copolymers with ionic and nonionic water-soluble segments (block ionomers) that are electrostatically coupled with oppositely charged species. Such polyion complex micelles (also termed block ionomer complexes) have high colloidal stability due to steric repulsion of their corona and often assume a spherical core-shell morphology. These species are currently actively researched for the delivery of various low molecular weight drugs and protein or nucleic acid-based therapeutics. This paper highlights recent advances in the development of cross-linked polymeric micelles, the physicochemical aspects of the formation and behavior of various block ionomer complexes, the strategies for the cross-linking of core and shell parts of the micelles, and the advantages and major challenges in their biomedical applications.
AB - Polymeric micelles formed as a result of the self-assembly of block copolymers constitute an important class of supramolecular structures that attracted attention as drug carriers in drug delivery and nanomedicine. Chemical stabilization of the polymeric micelles by introducing cross-links between block copolymer chains can increase stability and prevent premature disintegration of these micelles in the body. The cross-linking strategy has been also applied to a special class of polymeric micelles formed by block copolymers with ionic and nonionic water-soluble segments (block ionomers) that are electrostatically coupled with oppositely charged species. Such polyion complex micelles (also termed block ionomer complexes) have high colloidal stability due to steric repulsion of their corona and often assume a spherical core-shell morphology. These species are currently actively researched for the delivery of various low molecular weight drugs and protein or nucleic acid-based therapeutics. This paper highlights recent advances in the development of cross-linked polymeric micelles, the physicochemical aspects of the formation and behavior of various block ionomer complexes, the strategies for the cross-linking of core and shell parts of the micelles, and the advantages and major challenges in their biomedical applications.
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U2 - 10.1016/j.mencom.2013.07.001
DO - 10.1016/j.mencom.2013.07.001
M3 - Article
AN - SCOPUS:84881188761
SN - 0959-9436
VL - 23
SP - 179
EP - 186
JO - Mendeleev Communications
JF - Mendeleev Communications
IS - 4
ER -