TY - JOUR
T1 - Crosstalk between stem cell and cell cycle machineries
AU - Kareta, Michael S.
AU - Sage, Julien
AU - Wernig, Marius
N1 - Funding Information:
The authors thank members of the Wernig and Sage laboratories for critical comments on the manuscript. This work was supported by the Lucile Packard Foundation for Children's Health (MSK, JS), and the NIH (grant CA114102 to JS). MW is a New York Stem Cell Foundation-Robertson Investigator and a Tashia and John Morgridge Faculty Scholar, and JS is the Harriet and Mary Zelencik Scientist in Children's Cancer and Blood Diseases.
Publisher Copyright:
© 2015.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.
AB - Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.
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U2 - 10.1016/j.ceb.2015.10.001
DO - 10.1016/j.ceb.2015.10.001
M3 - Review article
C2 - 26520682
AN - SCOPUS:84946228841
VL - 37
SP - 68
EP - 74
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -