Crosstalk between stem cell and cell cycle machineries

Michael S. Kareta, Julien Sage, Marius Wernig

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume37
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Cell Biology

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