TY - JOUR
T1 - CSF proteomic fingerprints for HIV-associated cognitive impairment
AU - Laspiur, Juliana Pérez
AU - Anderson, Eric R.
AU - Ciborowski, Pawel
AU - Wojna, Valerie
AU - Rozek, Wojciech
AU - Duan, Fenghai
AU - Mayo, Raul
AU - Rodríguez, Elaine
AU - Plaud-Valentín, Marinés
AU - Rodríguez-Orengo, José
AU - Gendelman, Howard E.
AU - Meléndez, Loyda M.
N1 - Funding Information:
Financial support: Supported by the National Institutes of Health grants NINDS U54 NS4301, RCMI-CRC-1P20RR11126, R01 NS34239, R37 NS36136 and NCRR-RCMI G12 RR-03051 and the Carol Swarts, M.D. Laboratory for Emerging Neuroscience Research supported this work.
PY - 2007/12
Y1 - 2007/12
N2 - Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.
AB - Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.
KW - Biomarkers
KW - CSF
KW - HIV-associated cognitive impairment
KW - Proteomics
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UR - http://www.scopus.com/inward/citedby.url?scp=36749096223&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2007.08.004
DO - 10.1016/j.jneuroim.2007.08.004
M3 - Article
C2 - 17950469
AN - SCOPUS:36749096223
SN - 0165-5728
VL - 192
SP - 157
EP - 170
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -