CSF proteomic fingerprints for HIV-associated cognitive impairment

Juliana Pérez Laspiur, Eric R. Anderson, Pawel Ciborowski, Valerie Wojna, Wojciech Rozek, Fenghai Duan, Raul Mayo, Elaine Rodríguez, Marinés Plaud-Valentín, José Rodríguez-Orengo, Howard E. Gendelman, Loyda M. Meléndez

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)157-170
Number of pages14
JournalJournal of Neuroimmunology
Volume192
Issue number1-2
DOIs
StatePublished - Dec 2007

Keywords

  • Biomarkers
  • CSF
  • HIV-associated cognitive impairment
  • Proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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