CuHerbDB-for pharmacogenomics and study of phytochemicals in culinary and medicinal herbs

Suganya Chandrababu, Dhundy R. Bastola

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Drug development using plant sources is an important and fast evolving area. Plants contain valuable phytochemicals that possess a wide variety of curative functions including antibacterial, antifungal, anti-carcinogenic, enzyme stimulating, and many more. The growing prevalence of chronic diseases and rising health care costs have renewed the interests of many researchers to collect, store and retrieve information on medically relevant phytochemicals. The renewed interest has opened the path for designing practical approaches to increase the biochemical productivity of medicinal plants using large-scale but low-cost solutions. However, the interactions between bioactive compounds from herbal-supplements and prescription drugs leading to serious clinical consequences has become a widespread safety concern. The key to achieving production goals as well as addressing safety concerns lie in our thorough understanding of secondary metabolism in plant. Hence, to elucidate the importance of phytochemicals, and to unveil the underlying metabolic mechanisms that could affect the nature and level of bioactive compounds in the herbs we consume, we have developed CuHerbDB-A graph based database, for efficient storage/retrieval and graphical presentation of botanical, biochemical and pharmacological data for culinary herbs, using a Neo4j database framework. This database is the first step towards integrating herbal data for pharmacogenomics, which can be currently used to identify and facilitate feasible drug production strategies using plant sources and to investigate ways to significantly enhance the quality of herbs, in an urban farm setting.

Original languageEnglish (US)
Title of host publicationProceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
EditorsIllhoi Yoo, Jane Huiru Zheng, Yang Gong, Xiaohua Tony Hu, Chi-Ren Shyu, Yana Bromberg, Jean Gao, Dmitry Korkin
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1787-1794
Number of pages8
ISBN (Electronic)9781509030491
DOIs
StatePublished - Dec 15 2017
Event2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 - Kansas City, United States
Duration: Nov 13 2017Nov 16 2017

Publication series

NameProceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Volume2017-January

Other

Other2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
CountryUnited States
CityKansas City
Period11/13/1711/16/17

Keywords

  • Culinary Herbs
  • Drought Stress
  • Graph Database
  • Neo4j
  • Pharmacogenomics
  • Phytochemicals

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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  • Cite this

    Chandrababu, S., & Bastola, D. R. (2017). CuHerbDB-for pharmacogenomics and study of phytochemicals in culinary and medicinal herbs. In I. Yoo, J. H. Zheng, Y. Gong, X. T. Hu, C-R. Shyu, Y. Bromberg, J. Gao, & D. Korkin (Eds.), Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 (pp. 1787-1794). (Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017; Vol. 2017-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2017.8217932