TY - JOUR
T1 - Current methods and new approaches to assess aqueous humor dynamics
AU - Toris, Carol B.
AU - Gagrani, Meghal
AU - Ghate, Deepta
N1 - Funding Information:
This paper was funded by an unrestricted departmental grant from Research to Prevent Blindness (CWRU).
Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Introduction: Aqueous humor and its dynamics (AHD) serve numerous functions to sustain ocular health and clear vision. Current methods to assess AHD have led to improved understanding of ocular physiology, pathologies caused by abnormal intraocular pressures (IOP), and treatments to return IOP to healthy levels. However, the assumptions and limitations inherent in these methods have been problematic. New methods on the horizon are showing promise to greatly advance the field. Areas covered: This review summarizes AHD assessment techniques in use today including the noninvasive methods of fluorophotometry, tonometry, tonography, venomanometry, and invasive methods of cannulation, infusion, dissection. It also mentions emerging methods utilizing advanced imaging methods, smart phones, cameras, and software. Expert opinion: Soon new techniques will become available to measure each parameter and even subparts of each parameter of AHD with increased speed, accuracy, and safety. Along with these new methods and the data they generate could emerge the next version of the Goldmann Equation. These new methods would make AHD an important tool in the clinic for precision medicine and in the lab for exploring AHD on a new level.
AB - Introduction: Aqueous humor and its dynamics (AHD) serve numerous functions to sustain ocular health and clear vision. Current methods to assess AHD have led to improved understanding of ocular physiology, pathologies caused by abnormal intraocular pressures (IOP), and treatments to return IOP to healthy levels. However, the assumptions and limitations inherent in these methods have been problematic. New methods on the horizon are showing promise to greatly advance the field. Areas covered: This review summarizes AHD assessment techniques in use today including the noninvasive methods of fluorophotometry, tonometry, tonography, venomanometry, and invasive methods of cannulation, infusion, dissection. It also mentions emerging methods utilizing advanced imaging methods, smart phones, cameras, and software. Expert opinion: Soon new techniques will become available to measure each parameter and even subparts of each parameter of AHD with increased speed, accuracy, and safety. Along with these new methods and the data they generate could emerge the next version of the Goldmann Equation. These new methods would make AHD an important tool in the clinic for precision medicine and in the lab for exploring AHD on a new level.
KW - Goldman equation
KW - Intraocular pressure
KW - aqueous humor dynamics
KW - fluorophotometry
KW - measurement methods
KW - tonography
KW - tonometry
KW - venomanometry
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U2 - 10.1080/17469899.2021.1902308
DO - 10.1080/17469899.2021.1902308
M3 - Review article
AN - SCOPUS:85104985139
SN - 1746-9899
VL - 16
SP - 139
EP - 160
JO - Expert Review of Ophthalmology
JF - Expert Review of Ophthalmology
IS - 3
ER -