Current perspectives on the regulation of the Ica operon and biofilm formation in Staphylococcus epidermidis

Paul D. Fey, Luke D. Handke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Staphylococcus epidermidis is a ubiquitous commensal found on the skin of humans and other mammals. However, due to an increase in invasive medical practices, S. epidermidis has become the most common pathogen isolated from blood in intensive care unit patients in the United States (1,2). The noted increase of S. epidermidis infections in seriously ill patients can be attributed to the ability of this organism to adhere to and form biofilm on the surface of biomaterials, including catheters. The molecular structure of staphylococcal biofilm and the genetics behind its production and regulation have been an active area of research since the early 1980s. This review will focus on loci that have recently been demonstrated to regulate the ica operon, the four gene operon that produces enzymes that synthesize staphylococcal biofilm, or polysaccharide intercellular adhesin (PIA).

Original languageEnglish (US)
Title of host publicationBiofilms, Infection, and Antimicrobial Therapy
PublisherCRC Press
Pages187-203
Number of pages17
ISBN (Electronic)9781420028232
ISBN (Print)9780824726430
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Chemistry(all)

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    Fey, P. D., & Handke, L. D. (2005). Current perspectives on the regulation of the Ica operon and biofilm formation in Staphylococcus epidermidis. In Biofilms, Infection, and Antimicrobial Therapy (pp. 187-203). CRC Press.