Current strategies to treat tuberculosis

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Tuberculosis (TB) has been a leading cause of death for more than a century. While effective therapies exist, treatment is long and cumbersome. TB control is complicated by the overlapping problems created by global inadequacy of public health infrastructures, the interaction of the TB and human immunodeficiency virus (HIV) epidemics, and the emergence of drug-resistant TB. After a long period of neglect, there is now significant progress in the development of novel treatment regimens for TB. Focusing on treatment for active disease, we review pathways to TB regimen development and the new and repurposed anti-TB agents in clinical development.

Original languageEnglish (US)
Article number2579
JournalF1000Research
Volume5
DOIs
StatePublished - 2016

Keywords

  • Bedaquiline
  • Clofazamine
  • Delamanid
  • Fluoroquinolones
  • Nitroimidazoles
  • Oxazolidinones
  • Pretonamid
  • Rifamycin
  • Tuberculosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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