Customizable Composite Fibers for Engineering Skeletal Muscle Models

Afsoon Fallahi, Iman K. Yazdi, Ludovic Serex, Emal Lesha, Negar Faramarzi, Farhang Tarlan, Huseyin Avci, Raquel Costa-Almeida, Fatemeh Sharifi, Chiara Rinoldi, Manuela E. Gomes, Su Ryon Shin, Ali Khademhosseini, Mohsen Akbari, Ali Tamayol

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Engineering tissue-like scaffolds that can mimic the microstructure, architecture, topology, and mechanical properties of native tissues while offering an excellent environment for cellular growth has remained an unmet need. To address these challenges, multicompartment composite fibers are fabricated. These fibers can be assembled through textile processes to tailor tissue-level mechanical and electrical properties independent of cellular level components. Textile technologies also allow control of the distribution of different cell types and the microstructure of fabricated constructs and the direction of cellular growth within the 3D microenvironment. Here, we engineered composite fibers from biocompatible cores and biologically relevant hydrogel sheaths. The fibers are mechanically robust to being assembled using textile processes and could support adhesion, proliferation, and maturation of cell populations important for the engineering of skeletal muscles. We also demonstrated that the changes in the coating of the multicompartment fibers could potentially enhance myogenesis in vitro.

Original languageEnglish (US)
Pages (from-to)1112-1123
Number of pages12
JournalACS Biomaterials Science and Engineering
Issue number2
StatePublished - Feb 10 2020


  • biotextiles
  • interpenetrating network hydrogels
  • organ weaving
  • reinforced fibers
  • skeletal muscles
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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