TY - JOUR
T1 - Cutting edge
T2 - CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis
AU - Reddy, Jay
AU - Waldner, Hanspeter
AU - Zhang, Xingmin
AU - Illes, Zsolt
AU - Wucherpfennig, Kai W.
AU - Sobel, Raymond A.
AU - Kuchroo, Vijay K.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Female B10.S mice are highly resistant to proteolipid protein (PLP) 139-151-induced experimental autoimmune encephalomyelitis (EAE) and depletion of PLP 139-151-reactive CD4+CD25+ regulatory T (Treg) cells can slightly increase their EAE susceptibility. Although male B10.S mice are moderately susceptible to EAE, we report that depletion of Treg cells in male B10.S mice before immunization with PLP 139-151 renders them highly susceptible to severe EAE with more CNS neutrophil infiltrates than nondepleted controls. Increased susceptibility is associated with an enhanced PLP 139-151-specific T cell response and greater production of IFN-γ, IL-6, and IL-17. Male CD4+ CD25- effector cells depleted of Treg cells proliferate to a greater degree than those from females in response to either anti-CD3 or PLP 139-151. These data suggest that because of their capacity to regulate potent autoaggressive effector cells, Treg cells partly contribute to the resistance to autoimmunity in the male mice.
AB - Female B10.S mice are highly resistant to proteolipid protein (PLP) 139-151-induced experimental autoimmune encephalomyelitis (EAE) and depletion of PLP 139-151-reactive CD4+CD25+ regulatory T (Treg) cells can slightly increase their EAE susceptibility. Although male B10.S mice are moderately susceptible to EAE, we report that depletion of Treg cells in male B10.S mice before immunization with PLP 139-151 renders them highly susceptible to severe EAE with more CNS neutrophil infiltrates than nondepleted controls. Increased susceptibility is associated with an enhanced PLP 139-151-specific T cell response and greater production of IFN-γ, IL-6, and IL-17. Male CD4+ CD25- effector cells depleted of Treg cells proliferate to a greater degree than those from females in response to either anti-CD3 or PLP 139-151. These data suggest that because of their capacity to regulate potent autoaggressive effector cells, Treg cells partly contribute to the resistance to autoimmunity in the male mice.
UR - http://www.scopus.com/inward/record.url?scp=27144480654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144480654&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.175.9.5591
DO - 10.4049/jimmunol.175.9.5591
M3 - Article
C2 - 16237044
AN - SCOPUS:27144480654
VL - 175
SP - 5591
EP - 5595
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -