CXCR2-dependent endothelial progenitor cell mobilization in pancreatic cancer growth

Aihua Li, Xiao J. Cheng, Aune Moro, Rakesh K. Singh, Oscar Joe Hines, Guido Eibl

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Neovascularization is essential for tumor growth. We have previously reported that the chemokine receptor CXCR2 is an important regulator in tumor angiogenesis. Here we report that the mobilization of bone marrow (BM)- derived endothelial progenitor cells (EPCs) is impaired in CXCR2 knockout mice harboring pancreatic cancers. The circulating levels of EPCs (positive for CD34, CD117, CD133, or CD146) are decreased in the bone marrow and/or blood of tumor-bearing CXCR2 knockout mice. CXCR2 gene knockout reduced BM-derived EPC proliferation, differentiation, and vasculogenesis in vitro. EPCs double positive for CD34 and CD133 increased tumor angiogenesis and pancreatic cancer growth in vivo. In addition, CD133+ and CD146+ EPCs in human pancreatic cancer are increased compared with normal pancreas tissue. These findings indicate a role of BM-derived EPC in pancreatic cancer growth and provide a cellular mechanism for CXCR2 mediated tumor neovascularization.

Original languageEnglish (US)
Pages (from-to)20-28
Number of pages9
JournalTranslational Oncology
Volume4
Issue number1
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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