Cyclam-based polymeric copper chelators for gene delivery and potential PET imaging

Jing Li, Yu Zhu, Stuart T. Hazeldine, Steven M. Firestine, David Oupický

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A series of reducible polycationic copper chelators (RPCs) based on 1,4,8,11-tetraazacyclotetradecane (cyclam) were synthesized by Michael addition. Molecular weight of the polycations was controlled by reaction stoichiometry and reaction conditions, resulting in polymers with molecular weights ranging from 4400 to 13 800. The cyclam moieties in the polycations retained their ability to form complexes with Cu(II). The presence of disulfide bonds in the polycations resulted in substantially lower cytotoxicity than control 25 kDa poly(ethyleneimine). RPC as well as their complexes with Cu(II) exhibited high transfection activity in vitro. The reported polycationic Cu(II) chelates represent promising nucleic acid delivery vectors with potential for future theranostic applications.

Original languageEnglish (US)
Pages (from-to)3220-3227
Number of pages8
JournalBiomacromolecules
Volume13
Issue number10
DOIs
StatePublished - Oct 8 2012

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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