Abstract
Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction.
Original language | English (US) |
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Pages (from-to) | 315-330 |
Number of pages | 16 |
Journal | Cells |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Jul 31 2015 |
Keywords
- Cilia
- History
- Review
- Signal transduction
- cGMP
ASJC Scopus subject areas
- General Medicine