Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction.

Original languageEnglish (US)
Pages (from-to)315-330
Number of pages16
Issue number3
StatePublished - Jul 31 2015


  • Cilia
  • History
  • Review
  • Signal transduction
  • cGMP

ASJC Scopus subject areas

  • General Medicine


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