Cycling of gut mucosal CD4 T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels

E. J. Ciccone, S. W. Read, P. J. Mannon, M. D. Yao, J. N. Hodge, R. Dewar, C. L. Chairez, M. A. Proschan, J. A. Kovacs, I. Sereti

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4 T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samples were collected from viremic, untreated, HIV-infected participants, patients treated with prolonged ART (>5 years), and uninfected controls and analyzed by flow cytometry. In the gut, the proportion of cycling T cells decreased and the number of CD4 T cells normalized in treated patients in parallel with Β7 expression on CD4 T cells in blood. Cycling of gut T cells in viremic patients was associated with increased plasma LPS levels, but not colonic HIV-RNA. These data suggest that gut T-cell activation and microbial translocation may be interconnected whereas prolonged ART may decrease activation and restore gut CD4 T cells.

Original languageEnglish (US)
Pages (from-to)172-181
Number of pages10
JournalMucosal Immunology
Volume3
Issue number2
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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