TY - JOUR
T1 - CYP2E1-catalyzed alcohol metabolism
T2 - Role of oxidant generation in interferon signaling, antigen presentation and autophagy
AU - Osna, Natalia A.
AU - Donohue, Terrence M.
PY - 2013/5/29
Y1 - 2013/5/29
N2 - Cytochrome P450 2E1 (CYP2E1) is one of two major enzymes that catalyze ethanol oxidation in the liver. CYP2E1 is also unique because it is inducible, as its hepatic content rises after continuous (chronic) ethanol administration, thereby accelerating the rate of ethanol metabolism and affording greater tolerance to heavy alcohol consumption. However, the broad substrate speci fi city of CYP2E1 and its capacity to generate free radicals from alcohol and other hepatotoxins, places CYP2E1 as a central focus of not only liver toxicity, but also as an enzyme that regulates cytokine signaling, antigen presentation, and macromolecular degradation, all of which are crucial to liver cell function and viability. Here, we describe our own and other published work relevant to the importance of CYP2E1- catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury.
AB - Cytochrome P450 2E1 (CYP2E1) is one of two major enzymes that catalyze ethanol oxidation in the liver. CYP2E1 is also unique because it is inducible, as its hepatic content rises after continuous (chronic) ethanol administration, thereby accelerating the rate of ethanol metabolism and affording greater tolerance to heavy alcohol consumption. However, the broad substrate speci fi city of CYP2E1 and its capacity to generate free radicals from alcohol and other hepatotoxins, places CYP2E1 as a central focus of not only liver toxicity, but also as an enzyme that regulates cytokine signaling, antigen presentation, and macromolecular degradation, all of which are crucial to liver cell function and viability. Here, we describe our own and other published work relevant to the importance of CYP2E1- catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury.
KW - Antigen
KW - CYP2E1
KW - Degradation
KW - Ethanol
KW - Liver
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U2 - 10.1007/978-94-007-5881-0_6
DO - 10.1007/978-94-007-5881-0_6
M3 - Article
C2 - 23400922
AN - SCOPUS:84905321988
SN - 0306-0225
VL - 67
SP - 177
EP - 197
JO - Sub-Cellular Biochemistry
JF - Sub-Cellular Biochemistry
ER -